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Gut microbe-derived metabolite trimethylamine n-oxide induces cardiac hypertrophy and fibrosis

3Doses are usually increased gradually to help limit side effects

The litigation is called: MDL -3163 IN RE: Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) Non-Arteritic Anterior Ischemic Optic Neuropathy Products Liability Litigation

These findings identify Nav1.6 channelopathy as an early, selective defect within the Vmes circuit, potentially triggering bruxism, TMDs, and ALS-associated motor disturbances (Seki et al., 2019)

But other first-generation GLP-1s approved for diabetes or obesity, including dulaglutide (Trulicity) and liraglutide (Saxenda), may be sold as generics within the coming year